Sirius by Olaf Stapledon
Deadly serious and heart-breaking, Stapledon’s work about a dog imbued with human-level intelligence while retaining his canine attributes and his deep bond with his human creator’s daughter is a landmark in science fiction’s reach to explain humanity through the possibilities of the future and its own persistent prejudices and fear.
Heart of a Dog by Mikhail Bulgakov
On the other hand, turning a dog into a human is a perfect vehicle for satire, and Bulgakov’s skill at critiquing the burgeoning Soviet state, its fascination with human improvement, total control, and junk science through our hero dog’s evolution is a laugh aloud pleasure.
Nop’s Trial by Donald McCaig
Real dogs with remarkable skills are not unusual, and border collie Nop, a working sheepdog, is among the best. But once stolen and abused, Nop reveals an inner strength and loyalty beyond his previous experience that pulls him through these trials, endurable only through the bond between him and his owner.